PhD students


Bertrand FOUGERE

Subject: Méthodologie et biostatistique

Thesis subject

In Cluster Randomized Trials, units of randomization are groups of individuals, also called clusters, rather than individuals themselves. Such designs involve considering correlations between individuals of a same cluster. Trials involving older adults are sometimes carried out in nursing homes (NH) that are therefore the units of randomization. Residents leaving in NH are often frail and a third of them deceased in the first year after their admission. When trials are planned in such setting the problem of discontinuation due to death must be added to the problem of correlation. The problem of the management of discontinuation has 2 levels:
- The choice of the optimal design (« closed cohort », « open cohort », « continuous recruitment with short exposure »), depending on the intervention and on the outcome,
- If a closed-cohort is the selected design, the statistical analysis strategy to estimate the intervention effect without bias.
This PhD aims to contribute to answering those 2 problems.
Illustration 'About-us'


icon publication

Prognostic value of Charlson Comorbidity Index in the elderly with a cardioverter defibrillator implantation

Poupin P, Bouleti C, Degand B, Paccalin M, Le Gal F, Bureau M-L, Alos B, Roumegou P, Christiaens L, Ingrand P, Garcia R

International Journal of cardiology
2020, 314:64-69
icon publication

Helping Nursing Homes to Manage the COVID-19 Crisis: An Illustrative Example from France.

Aïdoud A, Poupin P, Gana W, Nkodo JA, Debacq C, Dubnitskiy-Robin S, Fougère B

Journal of American Geriatric Society
Novembre 2020. 68(11):2475-2477
icon publication

Analysis of the Impact of Selected Vitamins Deficiencies on the Risk of Disability in Older People.

Gana W, De Luca A, Debacq C, Poitau F, Poupin P, Aidoud A, Fougère B.Gana W, et al

2021 Sep 10;13(9):3163
Illustration publications


UE de santé publique. UFR pharmacie. Université de Tours

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